I attend Worldcon about once every five years--I enjoy it a lot, but I also enjoy my local cons, and they're a lot cheaper and easier to get to! If you don't have experience with traditional SF&F con-going fandom, I'd recommend checking out some in your area before committing to Worldcon--it will give you a sense of whether it's the sort of thing you like, and also it will help you meet people who'll be attending Worldcon. Worldcon is much more fun if you know people there--and I don't just mean a couple people who you're specifically attending with, although those are good to have, but random people you vaguely recognize in the con suite who you can strike up a conversation with over slightly stale pretzels and apple juice.
If you do go to Worldcon with people, I at least find it a lot more fun if we acknowledge right at the beginning that our interests are not in perfect alignment and that we're all free to go do our own thing, with plans to reconvene for meals or a few specific panels or presentations of shared interests. If nothing else, all doing your own thing means you've got more to talk about at dinner. Personally, I have a limited tolerance for panels--they always all sound super exciting in the run-up to the convention, and I go through the program with a highlighter and flag 2-3 things per time slot, but when it comes to actually attending them, I can do about 3 a day before I burn out. So I try to supplement with other things: time in the game room to feed my need for interaction, time just sitting in the video room to let my brain rest, time attending dances or yoga or walks with the stars to get some physical activity in the mix. My best experiences with panels are when I pick them based on panelists who I know are interesting speakers rather than based on topics.
I like kaffeeklatches and craft workshops a lot--they also feed my need for interaction--and those tend to require advance sign-up. One of the first things I do at a con is figure out what the sign-up system is and when and where I need to be for sign-ups (often sign-up sheets will be presented one day at a time, appearing the previous evening; sometimes they'll be put out in half-day chunks instead). Like book signings, filling out the sign-in sheets for limited-space events is something you sometimes need to budget 30-60 minutes of queuing time for. It's worth it for me.
What I don't tend to leave a lot of time for is meals. My goal is to have one sit-down meal every day (with friends), and to make sure I carry enough granola bars, fruit, sandwiches, or other snacks that I can eat when time does present itself without needing to hunt down more food. If I'm staying on site and can get a fridge in my room, that makes things even easier. (Staying on-site is always best if I can possibly swing it, IMO.)
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If you do go to Worldcon with people, I at least find it a lot more fun if we acknowledge right at the beginning that our interests are not in perfect alignment and that we're all free to go do our own thing, with plans to reconvene for meals or a few specific panels or presentations of shared interests. If nothing else, all doing your own thing means you've got more to talk about at dinner. Personally, I have a limited tolerance for panels--they always all sound super exciting in the run-up to the convention, and I go through the program with a highlighter and flag 2-3 things per time slot, but when it comes to actually attending them, I can do about 3 a day before I burn out. So I try to supplement with other things: time in the game room to feed my need for interaction, time just sitting in the video room to let my brain rest, time attending dances or yoga or walks with the stars to get some physical activity in the mix. My best experiences with panels are when I pick them based on panelists who I know are interesting speakers rather than based on topics.
I like kaffeeklatches and craft workshops a lot--they also feed my need for interaction--and those tend to require advance sign-up. One of the first things I do at a con is figure out what the sign-up system is and when and where I need to be for sign-ups (often sign-up sheets will be presented one day at a time, appearing the previous evening; sometimes they'll be put out in half-day chunks instead). Like book signings, filling out the sign-in sheets for limited-space events is something you sometimes need to budget 30-60 minutes of queuing time for. It's worth it for me.
What I don't tend to leave a lot of time for is meals. My goal is to have one sit-down meal every day (with friends), and to make sure I carry enough granola bars, fruit, sandwiches, or other snacks that I can eat when time does present itself without needing to hunt down more food. If I'm staying on site and can get a fridge in my room, that makes things even easier. (Staying on-site is always best if I can possibly swing it, IMO.)