I don't have any special yen for genderswap; I've written exactly one genderswap for a remix, I have one languishing in WIPs...but for me, it's like any other AU.

Change one key factor and see what else changes with it. The dynamic between any two characters changes if one of them is changed in some fundamental way. So what form does that change take? What stays the same and what's different? How does that make the characters the same or different?

It's just another form of exploration.